Nature - Rolling back of human pluripotent stem cells to an 8-cell embryo-like stage
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.Upon fertilization, the quiescent zygote experiences a burst of genome activation that initiates a short-lived totipotent state. Understanding totipotency in human cells would have very broad implications.
, a master regulator of DNA methylation in oocytes. induces DNA demethylation throughout the 8CLC conversion, whereas TPRX1 is a key executor of the 8CLC gene networks. We further demonstrate that 8CLC can produce embryonic and extraembryonic lineages in vitro or in vivo in the form of blastoidsand complex teratomas. Our approach provides a window to uncover the molecular logic of early human embryogenesis.
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