Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance - Nature

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Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance - Nature
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Nature research paper: Reversible RNA phosphorylation stabilizes tRNA for cellular thermotolerance

polysulfide solution was added instead of elemental sulfur, and the media were solidified with 1.0% Gelrite . When0medium for construction of the gene knockout strain.For small-scale preparation , archaeal cells were resuspended in 3 ml solution D , 0.5% -lauroylsarcosine sodium salt and 1 mM 2-mercaptoethanol) and mixed with an equal volume of water-saturated phenol and 1/10 volume of 3 M sodium acetate .

The mixture was shaken for 1 h on ice to which 106 ml chloroform/isoamyl alcohol was added, followed by centrifugation at 4,500for 20 min at 4 °C. The supernatant was collected and mixed with 106 ml chloroform/isoamyl alcohol , followed by centrifugation at 4,500for 15 min at 4 °C. The aqueous phase was collected and then subjected to isopropanol precipitation.

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