Science, Space and Technology News 2024
Weill Cornell Medicine scientists have discovered that astrocyte receptors can have opposite effects on cognitive function in male and female preclinical models. Published in Cell Reports, the study reveals that astrocytes play a crucial role in sex-specific brain mechanisms. Focusing on the mGluR3 receptor, the research demonstrated that increasing its levels enhanced memory in older females while reducing it impaired memory in young females.
“Our study reveals that previously reported cognitive effects in males can’t be extrapolated to females,” said Dr. Anna G.
To understand if these divergent effects were unique to mGluR3 or reflected a broader feature of astrocytic receptor signaling, Dr. Meadows worked with co-author Dr. Adam L. Orr, an assistant professor of research in neuroscience in the Brain and Mind Research Institute and the Appel Alzheimer’s Disease Research Institute, to selectively stimulate different astrocytic receptors while mice performed tasks involving learning and memory.
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