University of Ottawa-led team found a new viral entry for SARS-CoV-2 and suggests it may be able to use proteins to infect a wider range of cells. One of the many pressing research undertakings by the scientific community amid the ongoing COVID-19 pandemic has focused on ways the coronavirus mana
and suggests it may be able to use proteins to infect a wider range of cells.COVID-19Now, in a study adding to the pool of knowledge about viral entry, Dr. Marceline Côté’s Faculty of Medicine lab and collaborators have published a highly compelling study showing a previously unrecognized entryway for SARS-CoV-2, the virus that causes COVID-19 and the driver of the global health crisis that’s transformed the world.
Previous studies have shown that SARS-CoV-2 as well as an earlier coronavirus, SARS-CoV-1, the virus behind the SARS outbreak in 2003, enter cells via two distinct pathways. The new research led by Dr. Côté’s lab shows a third entry route. Over a series of experiments starting in 2020, Dr. Côté’s research team discovered that SARS-COV-2 can enter cells in a metalloproteinase-dependent manner. The team describes a role for two matrix metalloproteinases—MMP-2 and MMP-9—in the activation of the spike glycoprotein.iScience
The team’s experiments showed that some variants clearly prefer the metalloproteinases for activation. For instance, the Delta variant, a more pathogenic variant that surged in 2021, commonly used metalloproteinases for entry. Its less pathogenic successor, Omicron, did not.
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