A research team led by Prof. Wang Junfeng from the Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS), has developed a novel heat-sensitive ferritin mutant and realized easy and efficient loading of the chemotherapy drug doxorubicin.
loading techniques for ferritin are complex and require strict reaction conditions including high temperatures and strong acids/bases. Ferritin-based nanomedicine has limited drug loading and protein recovery rates, limiting its clinical use.
Based on this discovery, they developed Ecut-HFn, a unique and highly heat-sensitive ferritin mutant, and achieved one-step drug loading at low temperatures with the help of copper ions.
France Dernières Nouvelles, France Actualités
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