Relationship between COVID-19 and chilblains Chilblains Coronavirus Disease COVID PLOSGPH MonashUni UniMelb MCRI_for_kids
By Tarun Sai LomteOct 23 2022Reviewed by Benedette Cuffari, M.Sc. A recent PLoS Global Public Health journal study discusses the associations between chilblains and coronavirus disease 2019 .
Chilblains, an inflammatory dermatologic condition, can affect the body's acral regions and frequently occurs in middle-aged adults and women. Previously, chilblains were not considered to be associated with infections until the COVID-19 pandemic. One systematic review concluded that increased expression of the angiotensin-converting enzyme 2 receptor utilized by the severe acute respiratory syndrome coronavirus 2 to gain entry into host cells in the skin might cause cutaneous manifestations of COVID-19.
Data for this study were processed according to POLAR's data de-identification decision-making framework. The authors conducted the retrospective cohort analysis between January 2017 and September 2021, in which inclusion criteria were diagnoses of chilblain, COVID-19, or suspected COVID-19 in any Victorian GP.
Study findings A total of 6,846 chilblain diagnoses were reported from January 2017 to September 2021 across the three PHNs. Chilblain distribution across the age groups was similar to that of the general population in Victoria. Moreover, 3,687 COVID-19 diagnoses and 4,688 suspected COVID-19 diagnoses occurred in the same period.
When the 95th percentile of the diagnoses of COVID-19 and suspected COVID-19 was compared to the 50th percentile, the risk ratios of chilblains were 5.72 and 3.23, respectively.
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