Benralizumab is a highly effective biologic for the management of severe eosinophil asthma.
, the researchers retrieved deidentified patient information from medical, laboratory, and pharmacy US insurance claims records from the PatientSource and DiagnosticSource databases and compared asthma exacerbation rates before and after treatment with benralizumab.
The cohort was stratified into three nonmutually exclusive groups consisting of 349 patients who had switched primarily from either omalizumab or mepolizumab biologics to benralizumab; 429 patients subdivided by closest to the index date blood eosinophil counts of <150, ≥150, 150-299,<300, and ≥300, and 419 patients with post data collection extended beyond 12 months to 18 or 24 months.
Comparable reductions also occurred with the cohort in which the biologic treatment was changed to benralizumab. A greater effect was observed when the switch was made from omalizumab to benralizumab with a pre-post PPY rate reduction of 3.25 to 1.25 than when the switch was made from mepolizumab . Likewise, the results from the extended follow-up 24-month subgroup presented significant down trending exacerbation rates from pre-index 3.38 PPY to 1.38 for the first 12 months continuing down to 1.08 PPY over the 12–24 month post-index period . In the first and second 12 post-index months for the 24-month subgroup, 39% and 49% of the patients, respectively, experienced no exacerbations
France Dernières Nouvelles, France Actualités
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