Growing Evidence Supporting the Protein Leverage Hypothesis The 'protein leverage' hypothesis suggests that humans consume more food when dietary protein is diluted, especially with modern processed diets. This behavior is increasingly seen as a major contributor to the obesity epidemic. Integrated
The human body prioritizes protein intake over other dietary components, leading to increased food consumption when protein is diluted in the diet. A paper from the Royal Society highlights this “protein leverage” as a significant factor in the rise of obesity, especially with the proliferation of fat and carbohydrate-rich processed foods.The “protein leverage” hypothesis suggests that humans consume more food when dietary protein is diluted, especially with modern processed diets.
The authors outline published studies that span mechanisms of protein appetite to show how the protein leverage effect interacts with industrially processed food environments and with changes in protein requirements across the life course to increase the risk of obesity. For example, changing requirements for protein at certain life stages , as well as a combined impact with changes in activity levels or energy expenditure . Because data indicate that children and adolescents also show protein leverage, the authors discuss the potential impact of exposure to a high-protein diet in preconception or early life in potentially setting up increased protein requirements and greater susceptibility to lower protein, processed diets in later years.
The authors conclude: “…it is only through situating specific nutrients and biological factors within their broader context that we can hope to identify sustainable intervention points for slowing and reversing the incidence of obesity and associated complications.” Reference: “Protein appetite as an integrator in the obesity system: the protein leverage hypothesis” 3 September 2023,
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