Propylene glycol prevents airborne transmission of respiratory viruses biorxivpreprint imperialcollege MRC_LMB Respiratory Propylene glycol Virology Virus
By Bhavana KunkalikarFeb 20 2023Reviewed by Benedette Cuffari, M.Sc. *Important notice: bioRxiv publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Approaches to reduce viral transmission The use of masks, physical distancing, lockdowns, and travel restrictions are some of the public health and societal strategies used to control respiratory virus transmission.
To determine whether PG has virucidal activity, the team studied the influenza A virus , which causes seasonal outbreaks among humans and birds. Infectivity was assessed by titrating IAV treated with various doses of PG. To test the translational ability of PG-mediated virucidal action against IAV, in vivo inhalation of IAV followed by treatment with PG was also assessed.
Study findings PG significantly inhibited IAV infection of cultured cells, whose virucidal activity was dependent on PG concentration and viral incubation period. IAV inactivation mediated by PG was temperature-dependent, as virucidal activity at skin and nasal temperature of 32°C and body temperature of 37°C relative to 20°C.
PG inactivated the SARS-CoV-2 IC19 strain with greater efficacy than when used to treat IAV infection. After one minute of 50% PG treatment at room temperature, the infectivity of SARS-CoV-2 declined by over 1,000-fold, thus demonstrating persistent virucidal activity. PG vapor attenuated the infectiousness of airborne SARS-CoV-2 and IAV in a dose-dependent manner and eliminated infection within a distance of less than 1 meter. Similar to PG in nebulized droplets, the vapor form of this treatment exhibited more effective virucidal activity as compared to PG in solution.
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