According to research conducted by Johns Hopkins Medicine, multiple variants of the SARS-CoV-2 virus can be blocked from replicating by the small molecule inhibitor RK-33. An efficient method of combating SARS-CoV-2, the virus that causes COVID-19, may be possible based on findings from a recent
According to research conducted by Johns Hopkins Medicine, multiple variants of theAn efficient method of combating SARS-CoV-2, the virus that causes, may be possible based on findings from a recent study by a research team led by Johns Hopkins Medicine that avoids the issue of waning immunity that is frequently noticed when current vaccines address emerging COVID variants.
Raman and his colleagues have been researching the connection between a protein called DDX3 and cancer for a number of years. DDX3 is anhelicase, a protein that unwinds the double-stranded RNA that controls many tumor cells, allowing the RNA’s genetic code to be read . This results in the formation of new cancer cells and the malignant expansion of the disease.
Along with testing RK-33’s impact on SARS-CoV-2 infectivity and reproduction, the researchers extended their study to determine if the inhibitory action observed was limited to specific variants of the virus or would be effective against multiple variants. They used RK-33 to target DDX3 in laboratory cells infected with four variants of SARS-CoV-2 — the original virus and the alpha, beta, and delta variants.
“Vaccines designed against the spike protein of one SARS-CoV-2 variant may not be as effective if a new variant has a mutated spike protein,” he explains. “The ability of RK-33 to inhibit DDX3’s unwinding of viral RNA for translation is independent of the spike protein, so it should remain effective against most variants.”
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