Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. The cells can no longer develop their characteristic shape and remain in a rather round form. The animals are infertile.
Mature spermatozoa are characterized by an head, midpiece and a long tail for locomotion. Now, researchers from the University Hospital Bonn and the Transdisciplinary Research Unit"Life & Health" at the University of Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice. The cells can no longer develop their characteristic shape and remain in a rather round form. The animals are infertile.
To investigate the role of the structural protein in spermiogenesis, Prof. Schorle's team generated a mouse model with a mutation in theusing gene-editing technology. This results in a complete loss of function of ACTL7B."Without ACTL7B, development is blocked, the cells often remain in a roundish shape, usually do not form the elongated, typical sperm shape and die to a large extent ," says first author Gina Esther Merges, a doctoral student in Professor Schorle's laboratory.
Researchers investigated how intestinal stem cells are controlled at the molecular level to remain stem cells or to develop into one of various intestinal cells. By studying mice lacking the protein ... Current tests for male fertility include measuring the concentration and motility of spermatozoa. However, other characteristics of sperm, such as their ability to follow a chemical trail to the egg, ...
Acute myeloid leukemia is the most common form of acute leukemia. It is characterized by an increase of malignant myeloid progenitor cells at the expense of mature blood cells. Only twenty-five ...Mummified Feces Reveals Pre-Columbian Cultures of the Caribbean Consumed a Diversity of Plants
France Dernières Nouvelles, France Actualités
Similar News:Vous pouvez également lire des articles d'actualité similaires à celui-ci que nous avons collectés auprès d'autres sources d'information.
Researchers solve protein mystery | ScienceDailyResearchers have uncovered that proteins use a common chemical label as a shield to protect them from degradation, which in turn affects motility and aging.
Lire la suite »
Tracking down environmental toxins | ScienceDailyPFAS, a family of highly fluorinated substances, represent a danger for humans and the environment. Particularly problematic members of this family, such as perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) appear to cause organ damage and cancer, as well as disrupting the endocrine system.
Lire la suite »
The race of water droplets | ScienceDailyHow fast does a droplet flow along a fiber? It depends on the diameter of the fiber... and also on its substructure! These are the findings of a study conducted by researchers who are interested in microfluidics, especially water harvesting in arid/semi-arid regions of our planet.
Lire la suite »
Desert News -- ScienceDailyRead all about the desert biome, including articles on desertification, semi-arid conditions and more.
Lire la suite »