Pig brain cells may have cured a sea lion's epilepsy—are humans next?

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Pig brain cells may have cured a sea lion's epilepsy—are humans next?
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Researchers say the procedure paves the way for a new strategy to treat epilepsy, but many questions remain

The patient’s seizures were getting more severe and increasingly frequent. One or two per month grew to several each week. Each burst of uncontrolled electrical activity sent shock waves through his injured brain, causing tremors and confusion. Unable to eat, his body weight dropped by nearly one-third in a few months. His health was deteriorating fast.

“If you can really focus the application of the therapy right where the seizures are generated, you could spare the other parts of the brain from some of the side effects that we see with taking medications,” she says.Lethargic and disoriented, Cronutt was taken in by Six Flags Discovery Kingdom in Vallejo, California, after getting stranded on land in 2017.

Baraban agreed to help, and in a matter of weeks they had assembled a team of neurosurgeons, researchers and veterinarians to help with the procedure.On the morning of Oct. 6, 2020, the 18-person team met outside an animal hospital near San Francisco. COVID-19 protocols meant that only a handful of people could be in the clinic’s operating room, so Cronutt was sedated on a gurney in the parking lot.

“I think he feels great,” says Baraban, who visits Cronutt regularly. “I could not be more pleased with his progress thus far.” The procedure can’t reverse damage already done to Cronutt’s brain, but it could prevent further damage by preventing subsequent seizures. Cronutt will likely still face some mental challenges, but his caretakers are now hopeful that he could live into his 30s—the typical lifespan of a sea lion in captivity.

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