Pathogenicity of SARS-CoV-2 viral components on human periodontal tissues and cells researchsquare PlymUni SARSCoV2 peridontal covid coronavirus COVID19 viral cells
By Bhavana KunkalikarFeb 23 2023Reviewed by Danielle Ellis, B.Sc. *Important notice: Research Square publishes preliminary scientific reports that are not peer-reviewed and, therefore, should not be regarded as conclusive, guide clinical practice/health-related behavior, or treated as established information.
Recent research has demonstrated that the human oral cavity may serve as a reservoir for SARS-CoV-2. COVID-19 can result in severe lesions of the oral mucosa and is likely associated with periodontal diseases. However, the impact of COVID-19 on human oral health needs thorough investigation. The team then investigated the ability of SARS-CoV-2 to infect periodontal ligament fibroblasts. The cells were treated with His Tag-conjugated spike protein, and the position of the spike protein was analyzed with an anti-His Tag allophycocyanin -conjugated antibody. This facilitated the determination of the location of the spike protein.
Results Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy The study showed that ACE-2 and TMPRSS2 were significantly expressed within the gingiva epithelium and PDL cells. In addition, epithelial cells as well as PDL fibroblasts, exhibited constant TMPRSS2 and ACE-2 expression.
The team also discovered a protein group that was suppressed both six and forty-eight hours after infection. Trifunctional enzyme subunit alpha , isoform 2 of long-chain specific acyl-CoA dehydrogenase, isoform cytoplasmic of fumarate hydratase, and cytochrome c oxidase subunit 2 were considerably down-regulated. They played an important role in mitochondrial function and beta-oxidation.
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