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," given their crucial role in generating energy. Yet the vital work of these organelles is often impaired in people with obesity, for reasons that remain unclear.are probably bad news, it's also unclear how that might influence obesity or the additional health problems it can cause.
Obesity is an excessive accumulation of fat in the body, which is commonly stored in adipose tissue. As Saltiel and team note, adipose tissue normally serves valuable mechanical and metabolic roles in the body, like cushioning organs and releasing cellular signaling molecules. RalA is a multipurpose molecule, the researchers note, and one of its roles is to break down mitochondria when they malfunction. But if RalA is overactive, their study suggests, it might interfere with the regular work of mitochondria, thus leading to a metabolic cascade.
The researchers demonstrated the effect RalA can have by deleting its associated gene in some mice, then feeding them a high-fat diet identical to that eaten by other mice still carrying the gene.
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