Smoking-triggered heart attacks could be prevented—new research explains how manmetuni
Plaque erosion is responsible for 25–30% of acute coronary syndromes and most frequently occurs on stenotic plaques where the endothelium is exposed to elevated flow. Plaque erosion is more commonly observed in smokers and younger patients, particularly women. Herein, we provide a novel pathway that links the smoking-induced upregulation of Nrf2 with endothelial detachment and identify OSGIN1&2 as key players in this process.
Dr Libby’s laboratory has received research funding in the last 2 years from Novartis. Dr Libby is on the Board of Directors of XBiotech, Inc. Dr Libby has a financial interest in XBiotech, a company developing therapeutic human antibodies. Dr Libby has a financial interest in TenSixteen Bio, a company targeting somatic mosaicism and clonal haematopoiesis of indeterminate potential to discover and develop novel therapeutics to treat age-related diseases.
© The Author 2023. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
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