Novel organoid models to study non-alcoholic fattyliverdisease _Hubrecht NatureBiotech
disease and help facilitate a better understanding of the disease biology. The results of the study are published inThe buildup of fat in the liver is an increasingly common disease worldwide, with over a quarter of the worldwide population affected. Having a fatty liver can lead to inflammation, impairment of liver function, and eventually result in scar tissue formation. Different causes can lead to the development of fatty liver, with diet and lifestyle being the most common contributors.
Live-imaging of fatty liver organoids treated with a drug shows the clearance of fat within the organoids within 3 days. Credit: Delilah Hendriks & Benedetta Artegiani. Copyright Hubrecht Institute.Now, the researchers have turned to organoids to establish three models that capture different triggers of fatty liver development. Firstly, they fed the organoids with a mixture of fatty acids to mimic a Western diet and witnessed the rapid development of fatty liver organoids.
Finally, the researchers also modeled genetic lipid disorders using CRISPR-Cas9 to investigate how these disorders influence the development of fatty liver disease. These mutant organoids spontaneously developed severe fatty livers as a result of a build-up of sugar-derived fats.
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