Called the nanofluidic drug-eluting seed (NDES), it delivers low-dose immunotherapy in the form of CD40 monoclonal antibodies (mAb).
In a significant groundbreaking medical development, researchers have created a tiny device, smaller than a grain of rice, to deliver drugs directly to the pancreatic tumor.
In the near future, this implantable nanofluidic device could be a game changer in treating pancreatic cancer. Nanomedicine experts at Houston Methodist Academic Institute developed the device.The nanofluidic drug-eluting seed delivers low-dose immunotherapy in the form of CD40 monoclonal antibodies .
As seen in murine models, the result was remarkable tumor shrinkage. Compared to traditional systemic immunotherapy treatment, this tumor reduction was achieved with a "fourfold decrease" in drug dosage.
"Our goal is to transform the way cancer is treated. We see this device as a viable approach to penetrating the pancreatic tumor in a minimally invasive and effective manner, allowing for a more focused therapy using less medication," said Alessandro Grattoni, co-corresponding author, in a
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