In what may be a watershed moment in the fight against tuberculosis, the world's most lethal infectious disease, an experimental new vaccine has protected about half the people who got it, scientists reported Tuesday.While a 50% success rate is hardly ideal -- the measles vaccine, by contrast, is
In what may be a watershed moment in the fight against tuberculosis, the world’s most lethal infectious disease, an experimental new vaccine has protected about half the people who got it, scientists reported Tuesday.
“The vaccine looks promising, and likely better than our century-old BCG vaccine,” said Dr. Mario C. Raviglione, a global health expert at the University of Milan who headed the WHO’s global tuberculosis program from 2003 to 2017. Of those who got two doses of the GSK vaccine, only 13 developed active tuberculosis during three years of follow-up, according to the new study published in The New England Journal of Medicine. By contrast, 26 of those who got a placebo progressed to active tuberculosis.
Because so many people die of tuberculosis, Dr. Seth Berkley, chief executive of Gavi, the Vaccine Alliance, a public-private partnership that buys vaccines for poor countries, said his agency would “certainly give the vaccine a hard look.” The new study, however, tested the vaccine only in people who were HIV-negative and whose blood tests showed they had latent tuberculosis.
That result — the opposite of what would normally be expected, she said — implied that the careful screening done by the GSK team for the clinical trial, which included taking medical histories and sputum samples, must have weeded out people with early-stage tuberculosis.
France Dernières Nouvelles, France Actualités
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