Researchers at the Francis Crick Institute have discovered that consuming large amounts of the commonly used artificial sweetener, sucralose, decreases the activation of T-cells, a crucial aspect of the immune system, in mice. If similar effects are observed in humans, sucralose could potentially
Scientists at the Francis Crick Institute discovered that high consumption of sucralose, a common artificial sweetener, lowers T-cell activation in mice, a crucial component of the immune system. While normal dietary consumption of sucralose is not harmful, these findings could potentially lead to therapeutic uses for patients with autoimmune diseases, where high doses of sucralose could help mitigate harmful effects of overactive T-cells.
The mice fed diets containing high doses of sucralose were less able to activate T cells in response to cancer or infection. No effect was seen on other types of immune cells. Instead, the researchers hope the findings could lead to a new way of using much higher therapeutic doses of sucralose in patients, building on the observation that when mice with T cell-mediated autoimmune disease were given a high-dose sucralose diet, this helped to mitigate the harmful effects of their overactive T cells.
Fabio Zani, co-first author and postdoctoral training fellow at the Crick, adds: “We do not want people to take away the message that sucralose is harmful if consumed in the course of a normal balanced diet, as the doses we used in mice would be very hard to achieve without medical intervention. Karis Betts, senior health information manager at Cancer Research UK, said: “This study begins to explore how high doses of sucralose could potentially be used in new treatment options for patients, but it’s still early days.
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