The most widespread reason for frailty in hereditary diseases and aging is muscle degeneration, which could stem from a lack of a crucial enzyme in the lipid biosynthesis pathway. A team of researchers at the Austrian Academy of Sciences' Institute of Molecular Biotechnology (IMBA) has studied how t
Muscle membrane-derived Giant Plasma Membrane Vesicles . These isolated large membrane units, coupled with advanced microscopy applications, enabled a close analysis of the architecture of the otherwise difficult-to-study cell membrane lipid bilayer, giving insight into an unknown pathological mechanism of a recently discovered, severe human inherited disease. Credit: Cikes/IMBA.
Lipids are ubiquitously present in biological membranes and are present at particularly high concentrations in the membranes of nerve cells and neural tissues. Following reports that PE-based molecules enhance the membrane rigidity of liposomes, Domagoj Cikes, the study’s co-corresponding author and a former postdoctoral researcher in the Penninger lab at IMBA, hypothesized that this lipidmay play an important role in tissues subjected to constant shear stress, such as muscle tissue.
“This prompted us to think that there must be an additional mechanism driving the pathology,” says Cikes. Indeed, the team showed that the organization of the cell membrane lipid bilayer played an additional role. “This represents a novel pathophysiological mechanism that might also be present in other lipid-related disorders,” says Cikes.
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