New mechanism uncovered behind osteoarthritis could inform new treatments NatureComms
Age-related matrix stiffening in articular cartilage initiates pathogenic mechanotransductive signaling, driving chondrocyte dysfunction as well as disrupted cartilage integrity through Klotho promoter hypermethylation. Portions of the figure were created with biorender.com. Credit: Ambrosio et al,Researchers in the United States and Japan have discovered a new mechanism that links age-related cartilage tissue stiffening with the repression of a key protein associated with longevity.
and trends in obesity. Osteoarthritis can significantly interfere with a person's ability to perform routine daily tasks; about half of adults with the condition are of working age, which impacts their ability to earn a living. Using advanced mass spectrometry technology, the researchers mapped out the trajectory of structural and protein changes in mice with knee osteoarthritis over the course of their lifetimes and according to sex. They then compared their findings to the current understanding of knee osteoarthritis in humans.
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