CAR T-cell therapy, a certain kind of cancer treatment in which the immune system’s T cells are programmed to attack tumor cells, is effective in mice with ovarian cancer, according to a study published in The Journal for ImmunoTherapy of Cancer. The researchers, who work at Karolinska Institutet, h
showed that CAR T-cell therapy is effective in treating ovarian cancer in mice. Researchers at Karolinska Institutet hope the results will lead to a clinical trial for women with the disease.
CAR T-cell therapy is a relatively new type of immunotherapy that involves extracting a patient’s immune cells from the blood and injecting them in a laboratory with a new gene that specifically attacks a molecule called a chimeric antigen receptor on the surface of the tumor cells. When returned to the patients, the T cells are more aggressive, and attack the cancer cells like guided missiles.
Many ovarian tumors contain mesothelin, and the researchers wanted to test three types of CAR molecule programmed to attack this particular protein. They therefore repeatedly exposed ovarian cancer cells to the programmed CAR T-cells in test tubes and conducted several experiments on mice.
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