Most disease-causing bacteria are known for their speed: In mere minutes, they can double their population, quickly making a person sick.
But just as dangerous as this rapid growth can be a bacterium's resting state, which helps the pathogen evade antibiotics and contributes to severe chronic infections in the lungs and blood, within wounds, and on the surfaces of medical devices. Now, scientists have discovered how long chains of molecules called polyphosphates are needed for bacteria to slow down movements within cells and let them enter this resting state.
"Many current antibiotics block bacterial growth, but bacteria spend a lot of their time not growing," says Lisa Racki, assistant professor in the Department of Integrative Structural and Computational Biology at Scripps Research and senior author of the new paper."We really need new and creative strategies for targeting bacteria's slow-growing and non-growing phases."
"This not only helps point in possible directions for treating pathogenic bacteria, but also reveals answers for fundamental questions about how things diffuse throughout a bacterial cell," says Racki.
Wounds And Healing Dentistry Healthy Aging Bacteria Microbes And More Microbiology Biotechnology And Bioengineering
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