Wrinkles in a small gene have widespread ramifications, lowering the pain threshold for a common type of pain.
Despite differences such as a heavier brow and more oblong shape, Neanderthal skulls housed brains similar to our own in volume. gene, which provides instructions for building highly important sodium channels in certain nerve cells. These protein structures permit sodium ions to flow into the cell, readying it to fire and communicate with other nerve cells.
“Our findings suggest that Neanderthals may have been more sensitive to certain types of pain,” said Kaustubh Adhikari, a geneticist at University College London, in. “But further research is needed for us to understand why that is the case, and whether these specific genetic variants were evolutionarily advantageous.”first identified a link between the Neanderthal substitutions and greater pain using the UK Biobank, which contains genetic information for a half-million people in the U.K.
The researchers carried out the pain experiments on a group of 1,963 people from Colombia, about 6 percent of whom carried all three variants.in 5,971 participants from Brazil, Chile, Colombia, Mexico, and Peru. The three Neanderthal variants were found most frequently in populations with higher proportions of Native American ancestry, such as the Peruvian population.
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