The mRNA technology used in some coronavirus vaccines is expected to have many other uses, including temporarily reprogramming heart cells to remove scarring
The mRNA approach, which involves only temporarily modifying these cells, could dramatically decrease costs.“CAR-T therapy has been a breakthrough, but it costs a lot,” says Aghajanian. “We’re hoping this is the next step in CAR-T-type technology that will allow more access. This type of thing you can get to developing countries, to remote areas.”
In this case, however, the lipid nanoparticles have antibodies attached to them that bind to T-cells. The team had already been working on their research before the vaccines, but Aghajanian says the mass roll-out of vaccines should make it easier to get other uses of lipid nanoparticles approved by regulators
mRNAs, by contrast, are temporary copies of genes used as templates by protein-making factories. They are not integrated into the genome and only persist for days. This means that adding mRNAs to T-cells doesn’t permanently alter them. In other words, it is a way of creating transient CAR T-cells. “It does its thing for a few days and then it is gone,” says Aghajanian.
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