A technique has been developed by researchers that could help fine-tune the production of monoclonal antibodies and other useful proteins. MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells using an approach based o
Using an approach based on the CRISPR gene-editing system, MIT researchers have developed a new way to precisely control the amount of a particular protein that is produced in mammalian cells. Credit: Matthew Daniels, edited by MIT News
Chen, who is now an assistant professor of biomedical sciences at the University of South Dakota, is one of the lead authors of the new study, along with former MIT Research Scientist Leonid Gaidukov and postdoc Yong Lai. Senior author Timothy Lu led the research as an MIT associate professor of biological engineering and of electrical engineering and computer science.
“The idea is to have a full-spectrum synthetic promoter system that can go from very low to very high, to accommodate different cellular applications,” Chen says. “The system has very high consistency over different cell types and different target genes,” Chen says. “This is a good starting point for thinking about regulating gene expression and cell behavior with a highly tunable, predictable artificial system.”
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