Scientists found that certain immune cells were more prone to inflammation three to five months after mild covid-19, though the changes faded a year later.
“We can show that the macrophages from people with mild covid-19 exhibit an altered inflammatory and metabolic expression for three to five months post-infection,” said study author Craig Wheelock, a lecturer at Karolinska’s department of Medical Biochemistry and Biophysics, in a. “Even though the majority of these people did not have any persistent symptoms, their immune system was more sensitive than that of their healthy counterparts.
The study has some caveats. For one, it’s based on a relatively small sample size, though the addition of a control group does lend more credibility. It’s also not clear how relevant these findings are to our understanding of long covid, since those patients weren’t being explicitly studied. The authors do note that about 16% of the people in their mild covid group reported persistent symptoms at the three to five month mark, which had dropped to zero people a year later.
“We would like to do a corresponding study in which we involve both people with severe covid-19 and people without covid-19 but who have another kind of respiratory disease, such as influenza,” said co-author Julia Esser-von Bieren, research group leader at the Helmholtz Center Munich and the Technical University of Munich. “We’ll then examine if what inflicts covid-19 patients also inflicts those with, say, seasonal influenza.
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