A Review published in the Journal of Headache and Pain discusses whether migraine attacks are of peripheral or central origin. Both mechanisms are likely involved in a migraine attack but the site of initiation is still debatable, say the authors.
Migraine-inducing neuropeptides like CGRP may exert their effects in the periphery but this does not provide evidence of a peripheral origin of spontaneous migraine attacks. Interestingly, drugs that provoke migraine attacks clinically generally do not cause migraine aura symptoms, even in patients who always experience aura during their spontaneous migraine attacks [
]. Thus, these substances likely exert their migraine-provoking effects peripherally and downstream as opposed to spontaneous migraine attacks that originate centrally and subsequently lead to peripheral effects.Methodological uncertainties limits inferences from reports on prodromal symptoms in migraine, which otherwise may assist our understanding of migraine attack initiation.
]. If these observations are confirmed, it would allow for investigations into the mechanisms that link migraine aura and migraine headache using neuroimaging, electrophysiology, and biochemistry.Beyond any doubt, migraine pain is modulated through activity of CGRP and other neuropeptides within the trigeminovascular system [
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A wearable ultrasound sensor provides real-time cardiac imagingIn a recent article published in the journal Nature, a team of researchers described a wearable ultrasonic device that allows cardiac function to be assessed directly in real-time, with improved coupling between human skin and the device, making the examination of the left ventricle during motion possible from different views.
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Research supports weight-neutral care for women with binge eating disordersIn a recent study published in the journal eClinical Medicine, researchers in the United States reported findings of qualitative research that they pursued to understand the perceived impact of weight stigma and weight-neutral care among women receiving treatment for binge eating disorder (BED) with type 2 diabetes. BED is the most common eating disorder in the United States (US).
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