Researchers investigate effects of tau proteins on microtubules within nervecells CharlesUniPRG nchembio
Video related to Fig. 1c. Structural changes in the microtubule lattice upon cooperative binding of tau. Time-lapse movie of tau-mCherry envelopes growing on a taxol-lattice microtubule. Twenty nanomolar tau-mCherry is added to an initially bent microtubule. The microtubule straightens out when the tau envelope forms in the curved region. Scale bar, 2 µm.Video related to Fig. 1e. Kinesin-1 walking on taxol- and GMPCPP-lattice microtubules in presence of elevated concentrations of tau.
Video related to Fig. 2a. Local extension of GDP-lattice microtubule induces tau envelope disassembly in the presence of taxol. Time-lapse movie of 20 nM tau-mCherry on a GMPCPP-capped GDP-lattice microtubule. At= 0 s, tau is removed from the solution and microtubules are bent using hydrodynamic flow. During the hydrodynamic flow, imaging buffer with 10 μM taxol is added to the measurement chamber.
Video related to Fig. 2a. Local extension of GDP-lattice microtubule does not induce tau envelope disassembly in the absence of taxol. Time-lapse movie of 20 nM tau-mCherry on GMPCPP-capped GDP-lattice microtubules. At= 0 s, tau is removed from the solution and microtubules are bent using hydrodynamic flow. During the hydrodynamic flow, imaging buffer without taxol is added to the measurement chamber.
Video related to Fig. 4e. Tau dissociates from microtubules in vivo strongly resembling tau envelope disassembly in vitro. Time-lapse movie of a single microtubule in a U-2 OS cell expressing eGFP-tau after the addition of 0.01 μM taxol at= 0 min. During the dissociation of tau from the microtubules, fissions appear in the tau density that disassemble from their boundaries, closely resembling tau envelope disassembly in vitro. Scale bar, 2 µm.Video related to Supplementary Figure 4d.
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