The blood-brain barrier acts as a security border for the brain, playing a vital role in protecting the delicate neurons inside. However, its strict admission policy can be a problem when it comes to dispatching drugs to treat brain diseases.
to make this happen. It regulates several important cellular processes, and in this study, the communications network was used to unlock the blood-brain barrier.
Key to the process was the molecule Unc5B, which is involved in regulating exchanges between blood vessels and surrounding tissue. Experiments showed that when this receptor was knocked out in mice, they died as embryos because their vasculature network failed to develop properly.
Tests on adult mice showed that an absence of Unc5B did indeed leave the blood-brain barrier open. From there, the researchers found their way to the Netrin-1 ligand – a binding substance – that controls how effective Unc5B is. Finally, an antibody was developed to block Netrin-1 and disrupt the Wnt pathway.
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