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Depending on the anti-Aβ drug class, these agents can accelerate loss of whole brain and hippocampal volume and increase ventricular volume. This has been shown for some of the beta-secretase inhibitors and with several of the anti-amyloid monoclonal antibodies, researchers note.
The effect of ARIA-inducing monoclonal antibodies on whole brain volume varied, with accelerated whole brain volume loss caused by donanemab and lecanemab . This was not observed with aducanumab and bapineuzumab. Monoclonal antibodies did not cause accelerated volume loss to the hippocampus regardless of whether they caused ARIA.
Finally, they add that drug companies that have conducted trials of anti-Aβ drugs should interrogate prior data on brain volume, report the findings, and release the data for researchers to investigate."I have been banging on about this for years," said Ayton."Unfortunately, my raising of this issue has not led to any response. The data are not available, and the basic questions haven't been asked .
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