The decades-long quest to develop a HIV vaccine has been dealt another major blow, with the 'last true candidate in development' failing to prevent infections any better than a placebo in late-stage clinical trials.
, which will study whether the vaccines are safe and can stimulate an immune response.
"Finding an HIV vaccine has proven to be a daunting scientific challenge," immunologist and former NIAID director Anthony Fauci"With the success of safe and highly effective COVID-19 vaccines, we have an exciting opportunity to learn whether mRNA technology can achieve similar results against HIV infection."
Trouble is, phase I safety trials are a long way from phase III trials that deliver data on whether a new vaccine is effective or not, so it will be many years until we see another candidate reach late-stage trials.health reporter Helen Branswell at Stat News, the latest trial results are a"harsh reminder" of the challenges in developing a HIV vaccine.
At least five experimental HIV vaccines, tested over nine trials, have failed in efficacy trials, Warren . He suspects the problem lies not in vaccine delivery systems – which have worked against COVID-19 – but in the immune targets that HIV vaccines are trying to hit.Branswell."We have the vehicles. We don't even know what passengers to put in the vehicles."
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