A large trial suggests the hallucinogen in magic mushrooms could treat severe depression.
Psilocybin, the hallucinogen in"magic mushrooms," may help treat severe depression, results from the largest-ever trial of the therapy show.
"The Phase 3 was worked out in consultation with the FDA," said lead author Dr. Guy Goodwin , the chief medical officer of Compass Pathways, the pharmaceutical company that ran the latest trial."That'll give us an immense amount of experience to take into the approval process," Goodwin told Live Science.
"These patients were naive to the psychedelic experience in 94% of cases" and therefore couldn't guess what dose they'd been given, Goodwin said. By comparison, a recent trial that tested psilocybin as a treatment for alcohol use disorder gave participants either psilocybin or the drug diphenhydramine . In that trial, the participants and supervising therapists correctly guessed which medication had been given in 90% of cases.
Meanwhile, the scores of the 10-milligram group dipped slightly but were not significantly different from those in the 1-milligram group. In that middle-dose group, 19% responded to treatment, as did 18% of the low-dose group; 9% and 8% of each group entered remission, respectively. Three months post-treatment, 20% of the 25-milligram group still showed a"sustained response," meaning their scores had fallen and remained low, compared to 10% of the 1-milligram group.
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