The compound in psychedelic mushrooms helped heavy drinkers cut back or quit entirely in the most rigorous test of psilocybin for alcoholism.
The new research, published Wednesday in JAMA Psychiatry, is “the first modern, rigorous, controlled trial" of whether it can also help people struggling with alcohol, said Fred Barrett, a Johns Hopkins University neuroscientist who wasn't involved in the study.
While it’s not known exactly how psilocybin works in the brain, researchers believe it increases connections and, at least temporarily, changes the way the brain organizes itself.“More parts of the brain are talking to more parts of the brain,” said Dr. Michael Bogenschutz, director of the NYU Langone Center for Psychedelic Medicine, who led the research.
Before enrolling in the study in 2018, Orr had five or six drinks every evening and more on weekends. She stopped drinking entirely for two years, and now has an occasional glass of wine. More than the talk therapy, she credits psilocybin. In an experiment like this, it's important that patients don't know or guess if they got the psilocybin or the dummy drug. To try to achieve this, the researchers chose a generic antihistamine with some psychoactive effects as the placebo.
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