Immune dysregulation occurring during acute infection in COVID-19 persists for several months post-infection, finds a study published in the Journal of Translational Medicine. The findings may help shed light on the pathophysiology of Long COVID.
: Table S2). Whole blood total RNA was hybridized to reporter and capture probes at 65 °C for 16 h using a thermal cycler . These hybridized samples were loaded onto the nCounter cartridge, and the post hybridization step and scanning were performed on the nCounter Prep Station and Digital Analyzer.In a subset of CCD samples with highly perturbed gene expression and in healthy donor controls, we performed cytokine analysis.
Age, sex, ethnicity, and Body Mass Index distributions were similar among the 162 CCD and 40 healthy donors . With respect to baseline complete blood counts, hemoglobin, platelets, and absolute basophil and eosinophil counts were similar among CCD and healthy donors.
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