A Review published in Cancer Cell International discusses the role of long non-coding RNAs in colorectal cancer, their value in tumor diagnosis, their role in treatment response and prognosis prediction, and the signaling pathways they are associated with.
]. In one study, LINC01559 was found to be downregulated in CRC compared to normal tissues and lower expression of LINC01559 in CRC patients indicated a poor prognosis; this study revealed the mechanism as negative regulation of the LINC01559/miR-106b-5p/PTEN axis in CRC progression and disclosed a new mechanism of METTL3-mediated m6A modification on LINC01559 [EMT is one of the important mechanisms of CRC metastasis.
found that the expression of lncRNA SATB2-AS1 in CRC tissues was significantly lower than in normal tissues, and its expression was related to tumor staging and prognosis [cell proliferation, invasion and migration in vivo and in vitroAnother study showed that SATB2-AS1 could inhibit metastasis of CRC cells and regulates Th1-type chemokine expression and immune cell density in CRC tissues; SATB2-AS1 could directly bind to WDR5 and GADD45A, and mediate the deposition of H3K4me3 in the SATB2...
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Development and validation of a protocol for characterizing lipid nanoparticles for RNA deliveryThis app note looks at how to meet regulatory needs in the characterization of lipid nanoparticles for RNA delivery.
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The rise in interracial relationships is changing who is affected by sickle cellThe absence of a consideration of modern-day shifts in society could lead to missed diagnoses and exclusion from testing and screening programs ✒️ DrYemisiBokinni for ipaperviews
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Targeting the overexpressed mitochondrial protein VDAC1 in a mouse model of Alzheimer’s disease protects against mitochondrial dysfunction and mitigates brain pathology - Translational NeurodegenerationBackground Alzheimer's disease (AD) exhibits mitochondrial dysfunctions associated with dysregulated metabolism, brain inflammation, synaptic loss, and neuronal cell death. As a key protein serving as the mitochondrial gatekeeper, the voltage-dependent anion channel-1 (VDAC1) that controls metabolism and Ca2+ homeostasis is positioned at a convergence point for various cell survival and death signals. Here, we targeted VDAC1 with VBIT-4, a newly developed inhibitor of VDAC1 that prevents its pro-apoptotic activity, and mitochondria dysfunction. Methods To address the multiple pathways involved in AD, neuronal cultures and a 5 × FAD mouse model of AD were treated with VBIT-4. We addressed multiple topics related to the disease and its molecular mechanisms using immunoblotting, immunofluorescence, q-RT-PCR, 3-D structural analysis and several behavioral tests. Results In neuronal cultures, amyloid-beta (Aβ)-induced VDAC1 and p53 overexpression and apoptotic cell death were prevented by VBIT-4. Using an AD-like 5 × FAD mouse model, we showed that VDAC1 was overexpressed in neurons surrounding Aβ plaques, but not in astrocytes and microglia, and this was associated with neuronal cell death. VBIT-4 prevented the associated pathophysiological changes including neuronal cell death, neuroinflammation, and neuro-metabolic dysfunctions. VBIT-4 also switched astrocytes and microglia from being pro-inflammatory/neurotoxic to neuroprotective phenotype. Moreover, VBIT-4 prevented cognitive decline in the 5 × FAD mice as evaluated using several behavioral assessments of cognitive function. Interestingly, VBIT-4 protected against AD pathology, with no significant change in phosphorylated Tau and only a slight decrease in Aβ-plaque load. Conclusions The study suggests that mitochondrial dysfunction with its gatekeeper VDAC1 is a promising target for AD therapeutic intervention, and VBIT-4 is a promising drug candidate for AD treatment.
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Characterization of retrovirus-based vectors used in gene and cell therapiesComprehensive and reliable characterization, along with accurate quantitation, are essential for ensuring the quality and efficacy of retrovirus-based vectors used in novel gene and cell therapies.
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Novel metabolic pathway that makes immunology more efficient revealedThe metabolic pathways that produce a specific type of T cell are distinct from previously assumed, according to findings from UMich. Read more from the research below!👇 metabolomics science cells
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