A study published in Diabetology & Metabolic Syndrome finds that serum 25-hydroxyvitamin D and vitamin D receptor are potentially valuable biomarkers for diagnosis and prognosis of diabetic foot ulcer and diabetic foot osteomyelitis.
]. Owing to the complexity of DFU pathogenesis, further investigation of the correlation between vitamin D insufficiency and DFU pathogenesis and its influencing factors is of paramount importance. Additionally, to the best of our knowledge, no clinical studies have attempted to elucidate the correlation between vitamin D deficiency and the incidence of DFO.
Therefore, in the present study, we aimed to further explore the levels of 25VD in peripheral blood and VDR expression in wound margin tissues of patients with DFU and DFO, and identify its correlation with treatment outcomes of DFU and DFO, including foot ulcer recurrence, healing, and amputation, and its value as a potential biomarker for the diagnosis of DFU and DFO.
. The study was approved by the medical ethics committee of the First Affiliated Hospital of Anhui Medical University , and written informed consent was obtained from all subjects.
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