The International Brain pH Project Consortium unveils groundbreaking findings in a large-scale animal model study, indicating altered brain pH and lactate levels as a transdiagnostic endophenotype in neuropsychiatric disorders with cognitive impairment.
This collaborative effort, involving 131 researchers across six countries, challenges existing notions and may pave the way for novel strategies in understanding and addressing biologically diverse and debilitating disorders impacting cognitive function.
This study, encompassing 109 strains/conditions of mice, rats, and chicks, including animal models related to neuropsychiatric conditions, reveals that changes in brain pH and lactate levels are a common feature in a diverse range of animal models of conditions, including schizophrenia/developmental disorders, bipolar disorder, autism, as well as models of depression, epilepsy, and Alzheimer's disease.
In this paper, the mechanistic insights into the reduction in pH and the increase in lactate levels remain elusive. However, it is known that lactate production increases in response to neural hyperactivity to meet the energy demand, and the authors seem to think this might be the underlying reason.a. Halim ND, Lipska BK, Hyde TM, Deep-Soboslay A, Saylor EM, Herman M, et al . Increased lactate levels and reduced pH in postmortem brains of schizophrenics: medication confounds.b.
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