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Alterations of the fecal microbiota in relation to acute COVID-19 infection and recovery - Molecular BiomedicinePeople with acute COVID-19 due to SARS-CoV-2 infection experience a range of symptoms, but major factors contributing to severe clinical outcomes remain to be understood. Emerging evidence suggests associations between the gut microbiome and the severity and progression of COVID-19. To better understand the host-microbiota interactions in acute COVID-19, we characterized the intestinal microbiome of patients with active SARS-CoV-2 infection in comparison to recovered patients and uninfected healthy controls. We performed 16S rRNA sequencing of stool samples collected between May 2020 and January 2021 from 20 COVID-19-positive patients, 20 COVID-19-recovered subjects and 20 healthy controls. COVID-19-positive patients had altered microbiome community characteristics compared to the recovered and control subjects, as assessed by both α- and β-diversity differences. In COVID-19-positive patients, we observed depletion of Bacteroidaceae, Ruminococcaceae, and Lachnospiraceae, as well as decreased relative abundances of the genera Faecalibacterium, Adlercreutzia, and the Eubacterium brachy group. The enrichment of Prevotellaceae with COVID-19 infection continued after viral clearance; antibiotic use induced further gut microbiota perturbations in COVID-19-positive patients. In conclusion, we present evidence that acute COVID-19 induces gut microbiota dysbiosis with depletion of particular populations of commensal bacteria, a phenomenon heightened by antibiotic exposure, but the general effects do not persist post-recovery.
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Covid rates drop across Lancashire with just one area remaining a concernThe number of areas with higher figures is declining
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BBC journalist ‘beaten and kicked by police’ during Covid protests in ChinaThe broadcaster said it was ‘very concerned’ after confirming cameraman Edward Lawrence ‘was attacked’ in Shanghai on Sunday.
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China Covid: BBC journalist detained by police during protestsEd Lawrence was beaten and arrested by Shanghai police while covering anti-government rallies.
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Chinese stocks drop as zero-Covid protests erupt across country\n\t\t\tExpert insights, analysis and smart data help you cut through the noise to spot trends,\n\t\t\trisks and opportunities.\n\t\t\n\t\tJoin over 300,000 Finance professionals who already subscribe to the FT.
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Long COVID brain fog and fatigue negatively impact all facets of daily lifeIn a recent study published in the International Journal of Environmental Research and Public Health, researchers explored the lived experiences of individuals with post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (PASC) to understand the impact of the symptoms such as fatigue and brain fog on the various aspects of life including employment, daily activities, and interpersonal relationships.
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