Inspired by the sea and the sky, a biologist invents a new kind of microscope

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Inspired by the sea and the sky, a biologist invents a new kind of microscope
France Dernières Nouvelles,France Actualités
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The device can be used to image samples floating in any type of liquid—even the insides of transparent organs—while retaining enough light to allow for high magnification.

Anyone who’s ever owned a telescope has probably tried looking through the wrong end to see whether it works in reverse—that is, like a microscope. Spoiler alert: It doesn’t.

“It’s nice to see even something as basic as a lens could still bring interest and there's still room there to do some work that would help a lot of people,” says Kimani Touissant, an electrical engineer at Brown University. He says the design could be useful in his work, in which he uses lasers to etch patterns into gels that mimic collagen and act as scaffolds for cells.

Enter Fabian Voigt, a molecular biologist at Harvard University and inventor of the new design. He was reading a book about animal vision when he encountered the odd case of scallops’ eyes. Unlike most animals, whose eyes feature retinas that send images to the brain, scallops have mantles covered with hundreds of tiny blue dots, each of which contains a curved mirror at its back.

So, Voigt and colleagues built a prototype based on those specs. Light enters from the top, passes through a curved plate that corrects for the mirror’s curvature, then bounces off a mirror to hit a sample and magnify it. The curved mirror can magnify the image much like a lens, Voigt says. It allows researchers to look at samples suspended in any kind of liquid, simplifying the process.

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