Nature research paper: Induction of mouse totipotent stem cells by a defined chemical cocktail
We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.In mice, only the zygotes and blastomeres from 2-cell embryos are authentic totipotent stem cells , capable of producing all the differentiated cells in both embryonic and extraembryonic tissues and forming an entire organism.
Here, we demonstrate induction and long-term maintenance of TotiSCs from mouse pluripotent stem cells by a combination of three small molecules, TTNPB, 1-Azakenpaullone, and WS6. These cells, which we designated as ciTotiSCs , resembled mouse totipotent 2C-embryo stage cells at transcriptome, epigenome and metabolome level. In addition, ciTotiSCs exhibited bidirectional developmental potentials and were able to produce both embryonic and extraembryonic cellsteratoma.
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