Nature - Increased Memory B Cell Potency and Breadth After a SARS-CoV-2 mRNA Boost
. Despite the reduced protection from infection, individuals that received 3 doses of an mRNA vaccine were highly protected from more serious consequences of infection. Here we examine the memory B cell repertoire in a longitudinal cohort of individuals receiving 3 mRNA vaccine dosesdose is accompanied by an increase in, and evolution of, anti-receptor binding domain-specific memory B cells.
Overall, more than 50% of the analyzed neutralizing antibodies in the memory compartment after a 3mRNA vaccine dose neutralized Omicron. Thus, individuals receiving 3 doses of an mRNA vaccine, have a diverse memory B cell repertoire that can respond rapidly and produce antibodies capable of clearing even diversified variants such as Omicron.
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