While there's no cure for lupus and treatments don't work for everyone with the disease, a new study shows a cancer therapy may kick hard-to-treat lupus into remission.
that occurs when the body’s immune system engages in friendly fire against its own skin, joints, bones, kidneys and heart, triggering a host of symptoms.Used to treat certain types of cancer, the therapy takes your body's own T-cells, trains them in the lab to recognize very specific cells, and then infuses them back into the body to do their job. In lupus, the therapy targets CD19, a protein on B cells.
Side effects in the new study were mild, he said. In cancer studies, this type of therapy has caused high fever and chills, trouble breathing, and cytokine release syndrome, which can happen as CAR-T cells multiply and release large amounts of inflammatory cytokines into the bloodstream.has really undergone a deep reset and behaves normally going forward.
“This is a very, very big deal,” said Hoang Nguyen, senior scientific program manager at the Lupus Research Alliance. Her organization supported the initial studies looking at CAR-T therapy in a mouse model of lupus.
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