Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial - Critical Care

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Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial - Critical Care
France Dernières Nouvelles,France Actualités
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A study in Crit_Care finds that after traumatic brain injury, continuous infusion of hypertonic saline solution (20%) is not associated with an increased risk of acute kidney failure from infusion to Day 28.

]. Patients aged from 18 to 80 years old and admitted in one of the 9 participating ICU for moderate-to-severe TBI patients were eligible. Moderate-to-severe TBI was defined as the association of a Glasgow Coma Score of 12 or lower and traumatic abnormal brain CT scan findings []. In the interventional group, TBI patients received a 1-h bolus of 7.5 to 15 g of NaCl immediately after randomization.

]. The current post hoc analysis uses patient-level data focused on metabolic disturbances and kidney function to evaluate potential side effects associated with a continuous infusion of HSS .The current study was approved by the Ethics Committee of Ile de France VIII in May 2017 and conducted in accordance with the principles of the Declaration of Helsinki. Written informed consent was provided to all eligible patients at inclusion or after they recovered the ability to consent.

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