How effective has the bivalent booster COVID vaccination been? Coronavirus Disease COVID bivalent booster Eurosurveillanc UMCUtrecht rivm
The adult participants of this study self-reported SARS-CoV-2 infection, most likely caused by the Omicron BA.1 subvariant that was predominant in the Netherlands during the study period. These adults had received a primary-series COVID-19 vaccination and one or two monovalent booster doses before the study initiation.
Background Immunology eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Data are scarce on estimates of the effectiveness of bivalent vaccination against SARS-CoV-2 infections, especially relative to currently used monovalent vaccines. A United States study recently documented that the Omicron-targeted bivalent vaccine conferred higher protection in individuals of different age groups than monovalent vaccination .
About the study In the present study, researchers recruited two cohorts comprising vaccinated participants aged 18 to 59 and 60 to 85 years from an ongoing prospective cohort study called VASCO. They used Cox proportional hazard models to estimate the effectiveness of bivalent vaccination compared to primary and monovalent booster vaccinations. The study model adjusted for age, gender, education, and the presence of a medical risk condition.
During most of the study period, the incidence of SARS-CoV-2 infection was lower among participants who received an Omicron BA.1-targeted bivalent booster vaccine than those who did not. It had relative vaccine effectiveness of 31% and 14% in 18 to 59-year-olds and 60 to 85-year-olds, respectively, accounting for each participant's infection history.
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