According to a recent mouse study presented at an American Heart Association convention, high blood pressure may accelerate the aging of bones. According to a recent study presented at the American Heart Association's Hypertension Scientific Sessions 2022 conference, young mice with high blood pr
According to a recent mouse study presented at an American Heart Association convention, high blood pressure may accelerate the aging of bones.Hypertension Scientific Sessions 2022 conference, young mice with high blood pressure exhibited bone loss and osteoporosis-related bone damage similar to older mice.
In order to study the potential link between hypertension and bone aging, researchers in the study compared young mice with artificially induced hypertension to older mice without hypertension. According to Hennen, the mice’s human age equivalents ranged from 47 to 56 years for the older mice and between 20 and 30 years for the younger mice. Twelve young mice were administered angiotensin II, a hormone that causes elevated blood pressure.
“Failure force translates into weaker bones. In the spine, bone weakness can lead to vertebral fractures later in life,” Hennen said. To assess the impact of inflammation on bone health of the mice, researchers analyzed the bone marrow using flow cytometry. This tool allowed researchers to identify individual cells and to sort out specific immune cells. In the hypertensive young mice, they found an increase in the number of inflammatory signaling molecules, indicating an increase in inflammation in the bones when compared to the young mice that did not receive angiotensin II.
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