Prevalence of Rhett Syndrome, globally, has stayed stable for 20 years, which may facilitate planning of therapeutic trials in this disease, finds a Systematic Review published in Systematic Reviews.
], though the Orphanet estimate is limited by lack of a published description of its methods and data sources.
No studies that included patients with RTT older than 35 years were included. Studies report that, after reaching 25 years of age, adults with RTT have a mortality rate similar to the general population []. If that is indeed the case, the pooled prevalence estimates presented could be extrapolated to the general population. However, future studies should include patients of all ages to determine if the prevalence changes with age.
The strengths of this study were that the results encompassed the prevalence estimates from several nations and covered many different patient populations. Similar estimates were obtained for many different populations, and the true prevalence of RTT did not vary substantially from one region to another. To supplement the clinical criteria, some studies also used theInternational Classification of Disease, Tenth RevisionThe present meta-analysis has several limitations.
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