Dozens of clinical trials are now underway for new forms of the mRNA vaccine—targeting everything from malaria to Zika, herpes, and cytomegalovirus.
. After Covid, they could be quickly repurposed to create vaccines for other diseases—all you need to do is change the order of the bases in the mRNA to give the body a new set of instructions. There are also far fewer concerns about purity or contamination than with traditional vaccines—the body quickly translates, expresses, and breaks down the strand of mRNA.
CEPI’s other goal is to improve access to mRNA vaccines, which still need to be stored and transported at extremely cold temperatures , which makes reaching remote areas challenging. The cold chain requirement and the cost are two reasons the majority of mRNA vaccines have been purchased and administered by higher-income countries.
Or, if that doesn’t work, there’s also the “sledgehammer” approach of putting multiple strains of mRNA into a single jab—a whole manual of instructions the body can use to recognize different strains of a virus. “Our goal ultimately is to develop these individual antigens but combine them in ways that if you’re getting a seasonal booster you don’t need to get multiple, you can get a single booster to cover against the most likely respiratory pathogens,” Miller says.
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