Exploring dynamics of emergence and spread of SARS-CoV-2 variants of concern medrxivpreprint SARSCoV2 COVID19 Emergence Spread Variants VOC
By Tarun Sai LomteDec 15 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers evaluated the emergence and spread of severe acute respiratory syndrome coronavirus 2 variants of concern in Canada.
The PHAC, Statistics Canada, and the National Microbiology Laboratory initiated a pilot program in October 2020 to test for SARS-CoV-2 in wastewater specimens collected twice/thrice a week 15 from sewage treatment plants in multiple cities, including Edmonton, Montreal, Vancouver, Halifax, and Toronto. Besides, wastewater sampling was performed five times a week from three plants in Winnipeg.
Related StoriesVOC proportions measured in wastewater were the percentages of variant alleles detected by assays. Due to limited data, wastewater data were not used to derive CIs or fit logistic models. Therefore, the growth rate of each variant was assessed using clinical data alone. Nonetheless, VOC proportions in wastewater were compared to those from clinical surveillance to assess similarities.
The Gamma VOC significantly circulated only in British Columbia, whereas the other three VOCs of interest circulated in all provinces. The Delta VOC spread at similar speeds across provinces, with Newfoundland and Labrador being the only outlier, likely due to the small sample size. Likewise, the Omicron VOC spread at a similar rate in provinces. SARS-CoV-2 Delta became predominant within four months.
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