Ever Had a Really Long Acid Trip? Now Science Knows Why

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Ever Had a Really Long Acid Trip? Now Science Knows Why
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Finally. (From 2017)

It should all be over after a few hours, right? OK maybe not. Eight? Ten? Probably should have cleared more of my calendar.

Now, your body will clear LSD from your bloodstream in a matter of hours. But not your brain. Specifically, not the serotonin receptors that LSD binds to in the claustrum region of the brain. “Once LSD gets in the receptor, you can think of it as a hole in the ground. LSD jumps into it and then pulls a lid down over the top,” says study co-author, a pharmacologist at the University of North Carolina at Chapel Hill School of Medicine.

Now, with the X-rays you get at the dentist, only 10 percent of the rays will actually hit an atom to produce an image. The same would go for trying to image crystallized receptors. So the researchers used the Argonne National Laboratory’s Advanced Photon Source to fire a concentrated beam of x-rays at the crystals. “Now if you shoot a lot more at them, you will get a lot more data out of it,” says Wacker, “because it'll always be 10 percent.

Now’s as good a time as any to remind readers that while LSD shows medical promise, it’s still very much illegal in the United States. And even if people could use it legally, those interested in it as a therapeutic might not want those pesky trips. "We can begin to determine whether the psychedelic experience is part and parcel of all the potential therapeutic effects,” Roth says.

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